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Motilium – one of the most well-known and widely-used drugs – used for 32 years in more than 90 countries around the world.

HISTORY Motilium

During the existence of the drug Motilium conducted many clinical studies that prove the high efficiency and safety of its active ingredient – domperidone. Domperidone was synthesized in 1974 in Belgium, thanks to scientific research company “Janssen Pharmaceutica.”
The founder and head of the company for many years was Paul Janssen (1926-2003). The contribution of this scientist in the modern pharmacology is huge. Paul Janssen was known in the scientific world as an exceptionally gifted researcher, who once made a revolution in some areas of medicine. It was under his leadership, it was synthesized by haloperidol, for decades has become a leader among the antipsychotics.
The company pioneered the creation of drugs of different groups, including antidiarrheal, the first of which was diphenoxylate, and a little later appeared and domperidone. Paul Janssen Research has focused on the creation of drugs that are primarily to meet the needs of society. The scientific activity has brought him numerous awards, including 5 honorary professorships and 22 doctoral degree. He was the author and co-author of over 850 scientific publications, as well as an honorary member of more than 30 scientific organizations.
Motilium originally had prescription status. Subsequently, due to the high level of safety of the drug has been granted the status of non-prescription. Interestingly, at home Motilium – Belgian – he became known for his protivorvotnomu effect.
The drug is available in a unique form – in the form of a lozenge with a pleasant mint flavor that instantly dissolves on tongue for 2-3 seconds and does not require zapivaniya water. Tablets for sucking produced by a unique patented technology Zydis

The international non-proprietary name
(INN): domperidone.

Chemical name: 5-chloro-1- [1- [3- (2,3-dihydro-
2-oxo-1H-benzimidazol-1-yl) propyl] -4-piperidinyl] –
1,3-dihydro-2H-benzimidazol-2-one

Composition
Active substance (1 tablet): 10mg of domperidone,
Excipients (for 1 tablet): Lactose
54,2mg monohydrate, corn starch 20mg,
microcrystalline cellulose 10 mg, prezhela-
tinizirovanny starch 3mg, 1.5mg povidone K90,
magnesium stearate 0,6mg, cotton seed oil hydro-
genizirovannoe 0.5 mg sodium lauryl sulfate
0,15mg.
Film shell: hypromellose 2910 5mPa × s,
Sodium lauryl sulfate 0.05 mg, purified water q.s.
(Deleted in the process).

Indications
For ease discomfort in the stomach:
Fullness and heaviness in the stomach
Pain in the upper abdomen
The feeling of bloating, flatulence, belching
Heartburn
If nausea and vomiting caused by malnutrition, viral infection, poisoning and others.

Dosing and Administration
Inside; preferably before meals; duration of use without a doctor’s recommendation – not more than 28 days.
Adults and children over 12 years: 1-2 tablets of 10 mg 3-4 times a day.
Children aged 5 to 12 years: 1 tablet of 10 mg 3-4 times a day.
Only for children weighing 35 kg or more! The maximum daily dose – 8 tablets (80 mg). D
A children weighing less than 35 kg should be used mainly suspension format.

Contraindications and special instructions
installed intolerance of the drug and its components; prolactin-secreting pituitary tumor (prolactinoma); concomitant use of oral forms of ketoconazole, erythromycin or other potent inhibitors of CYP3A4 isoenzyme, causing elongation of interval QT, such as fluconazole, voriconazole, clarithromycin, amiodarone, and telithromycin; gastrointestinal bleeding, mechanical obstruction or perforation (ie, when the stimulation of gastric motility might be dangerous..); liver dysfunction moderate and severe; phenylketonuria.
Children under 5 years of age (for a given dosage form);
Carefully
Renal function, violation of rhythm and conduction of the heart, including the lengthening of the interval QT, electrolyte disturbances, congestive heart failure.
Pregnancy and lactation
Data on the use of Motilium during pregnancy is not enough. It should be used by a doctor during pregnancy only if its use is justified by the expected therapeutic benefit.
It is not known if the active drug substance in breast milk negative effect on infants. In this regard, when applying Motilium during lactation should stop breastfeeding.

Interactions with other medicinal
REMEDIES
Anticholinergic drugs can neutralize Call action Motilium drug. The oral bioavailability of the drug Motilium decreases after prior reception cimetidine or sodium bicarbonate. Do not do it take antacids and antisecretory preparations Rata together with domperidone, since they reduce its bioavailability after oral administration.The main role in the metabolism of domperidone plays isoenzyme CYP3A4. Research results in vitro and clinical experience show that onetemporary use of drugs, which significantly tional inhibit this isoenzyme may cause increase in plasma concentrations of domperidone.
Among the strong CYP3A4 inhibitors include:
• azole antifungals, such
* as fluconazole, itraconazole, ketoconazole *
and voriconazole *;
• Antibiotics, macrolides such as clarithromycin *
and erythromycin *;
• HIV protease inhibitors such as amprenavir,
atazanavir, fosamprenavir, indinavir, nelfi-
navir, ritonavir, and saquinavir;
• calcium antagonists such as diltiazem
and verapamil;
• Amiodarone *;
• aprepitant;
• Nefazodone.
• telithromycin *
(Drugs asterisk furthermore prolong the QTc interval (see. “contraindications section zaniya “)).
Several studies have pharmacokinetic and pharmacodynamic makodinamicheskih interactions domperidone ketoconazole orally with oral and erythromycin in healthy volunteers was It demonstrated that these drugs significantly inhibit the primary metabolism of domperidone, osuschestvlyaemy isoenzyme CYP3A4.
At the same time taking 10 mg of domperidone
4 times a day, and 200 mg of ketoconazole 2 times per day
QTc prolongation was noted in the average
9.8 ms for the entire period of observation,
at certain moments of change varied
from 1.2 to 17.5 msec. At simultaneous reception of 10 mg
domperidone 4 times a day, and 500 mg of erythromycin
3 times a day marked lengthening of the interval
QTc an average of 9.9 ms over the entire period
observation, in some moments changes
ranged from 1.6 to 14.3 msec. In each of these
Cmax and AUC of domperidone studies were in-
licheny about three times (see., “anti-partition
vopokazaniya “).
At the present time it is not known what contribution
the change in the QTc interval is made higher
domperidone plasma concentrations.
In these studies domperidone monotherapy
(10 mg four times a day) resulted in lengthening
QTc interval 1.6 msec (ketoconazole study)
and 2.5 msec (erythromycin study), then
as monotherapy ketoconazole (200 mg twice
daily) and erythromycin monotherapy (500 mg
tid) resulted in a lengthening of the interval
QTc 3.8 and 4.9 ms, respectively, during the
the observation period.
In another study using mnogokrat-
doses of healthy volunteers, was not detected
ruzheno significant lengthening of the QTc interval in
time stationary domperidone monotherapy
(40 mg four times a day, the total daily dose
160 mg, 2 times the recommended the maximum daily dose). At the same concentration
tration domperidone in plasma were similar tako-
Vym in interaction studies domperidone
with other drugs.
Theoretically, as has MOTILIUM
gastrokinetic action, it could affect
the absorption of both an
oral preparations, particularly preparations
The sustained-release
substance or drug coated kishechnorastvo-
Rima shell. However, the use of domperidone
in patients while taking paracetamol or digok-
sina not affect the levels of these drugs in the blood.
MOTILIUM can be taken together with:
• neuroleptics, the action of which it does not increase;
• dopaminergic receptor agonists
(Bromocriptine, levodopa) since it oppresses
their unwanted peripheral effects, such
like digestive disorders, nausea and vomiting,
without affecting their central effects.

STORAGE CONDITIONS
Store at temperatures between 15 and 30 ° C.
Keep out of the reach of children.
SHELF LIFE
5 years.
Do not use after the expiration date.
CONDITIONS OF RELEASE
Without recipe.
MANUFACTURER
“Janssen-Cilag”, France
Address place of production: «Janssen-Cilag»,
Domaine de Maigremont, 27100 Val de Reuil, France /
“Janssen-Cilag” Domaine de Megremon, 27100 Val
de Reuil, France

The work of the stomach – how to normalize it?
Stomach related to the upper gastrointestinal tract, in which there is an initial stage of digestion. Several factors can cause a violation of its functions. As a result, the unpleasant symptoms can occur: nausea, bloating and pain in the upper abdomen, a feeling of fullness and heartburn.
Bad habits, poor diet, sedentary lifestyle and lack of attention to their health and sooner or later may lead to normalization of the functions of the stomach becomes the number one task.
To understand the importance of the work of this body, it is necessary to get acquainted with the work he performs.
Healthy stomach is responsible for several successive processes which are indispensable for further digestion and normal absorption of nutrients in the gut.
Deposition
The food, previously processed with saliva in the mouth, “stored” in the stomach. This provides a uniform action of acids and digestive enzymes.
chemical treatment
Effects on food hydrochloric acid and gastric juice containing special enzymes, – the next stage of gastric operation that prepares the food to the next process.
Mechanical restoration
The walls of the stomach are reduced, which allows to grind the food and move it gradually to release in the intestine, wherein the other chemical elements have continued splitting nutrients, water absorption and extraction of all the necessary food elements useful.
Each of the stages is closely linked to other, so a violation of one of the processes inevitably entails consequences in the form of occasional or persistent problems with digestion.
With most clearly manifest themselves as problems with motor functions – promotion of food in the intestines. In poor or chaotic reduction of the stomach wall develops nausea, belching and other unpleasant symptoms. Sporadic cases of dysmotility may be associated with overeating, in the presence of a large number of menu “heavy” dishes – fried, fatty. At constant or regular symptoms of indigestion should reconsider the whole way of life and even consult a doctor.
What is necessary for normal functioning of the stomach
Proper nutrition
A diet and balanced diet – a factor of paramount importance for the normal functioning of the stomach. Compliance with specific eating schedule to stabilize the secretion of gastric juice and bring it back to normal motility. The diet must be present whole-grain cereals, fresh vegetables, fruits and hot meals first. It is useful to exclude from the menu of sweets and pastry, as well as fast food and smoked products.
Avoid snacking on the go and to allocate free time to receive food.
Strict restrictions on diet or mono-diet (unless they are prescribed by a doctor) can also cause damage to the stomach and cause persistent digestive disorders.
Active lifestyle
Healthy activity involves regular exposure to fresh air, playing mobile sports (in the absence of time or poor physical fitness even walking or cycling). Motor activity normalizes blood circulation and improves the flow of nutrients and oxygen to all the organs and tissues, among other things, has a positive effect on the digestive system.
Quitting smoking and alcohol abuse would also benefit the digestive tract and helps normalize the functioning of the stomach.
The absence of neuropsychiatric overload
The nervous system controls all the processes occurring in the body, including the digestive system. With increased levels of stress, excessive psycho-emotional experiences often develop symptoms of gastric motility disorders. This is due to incorrect regulation contractions and spasms of its walls, which leads to a chaotic movement of food, its retention in the stomach. As a result, may start to develop symptoms of gastrointestinal disorders work.
For the normalization of the stomach in this case requires not only the drugs that help eliminate dysmotility, but also a complete rest and elimination of nervous stress.
MOTILIUM Tablets promote the rapid izbavleniyu1 of slow digestive symptoms. According to their instructions can be used without a doctor’s prescription. However, if symptoms are observed for a long time or they occur suddenly and rapidly intensified, it is necessary to see a specialist for advice and possible treatment purposes.
1 – Peak plasma concentrations are reached within 30-60 minutes. According to the instructions for use of the drug.

Nausea and vomiting – the constant companions of many diseases of the digestive system. But, fortunately, in a majority of cases, these symptoms do not indicate a disease, but a temporary malfunction of the upper gastrointestinal tract. In such situations, the purpose of nausea and vomiting – catharsis of the “incorrect” contents: too much food, too greasy or spicy dishes, which before was eaten with pleasure, and so forth.
But let’s find out in more detail the characteristics of these symptoms, in order to understand why they occur and what can be called.
What is nausea and vomiting
At its core, vomiting – is a reflex, which is incorporated in the human body from birth, and it is a harbinger of nausea.
These states are developed under the influence of reactions of the nervous system. It is directly involved in regulating the functions of the digestive system. Jobs complex mechanism, involving the diaphragm, abdominal wall muscles, the sphincter of the stomach and even the brain (the “Control Center” vomiting is precisely therein), results in a simple and independent of the person act – the eruption of food through the mouth.
Manages the process the nervous system, so the vomiting and nausea may also have other symptoms such as pale skin, excessive salivation, the sudden appearance of the sweat, heart palpitations.
During vomiting there retrostalsis: stomach wall, which had to be reduced and to promote food to the intestines begin to work the other way around, moving it into the esophagus, and then – on the way out through the mouth.
Typically, if nausea was caused by overeating or heavy food intake, it is resolved independently – gastric emptying (vomiting) or after ingestion, reducing gastric motility correct.
But in addition there are other reasons for overeating.

How to cope with nausea and vomiting
The most common advice would sound like this: “Stick to bed rest, plenty of rest and go on diet food.”
But, unfortunately, the realities of modern life often require rapid removal of these symptoms in order to not break out of rhythm, and to maintain social activity.
In this case, the aid will come motilium that within a short time after ingestion helps normalize motor and evacuation function of the stomach, relieve nausea and vomiting. Its active ingredient – domperidone – activates contraction of the stomach wall in the right direction and blocking mechanisms causing movement of food in the opposite direction – up through the esophagus. Its acceptance does not require a doctor’s prescription, which allows you to deal with the problem of vomiting, even in “awkward” situations “- on the road, at work and so on.
Keep in mind that with vomiting, which occurred suddenly, without a direct connection with food intake, and / or characterized by increase of frequency and severity of retching, you need access to a doctor to determine the cause of this condition.

According to the results of statistical studies, about 45% of the world’s population – regardless of age, gender and social status – periodically experience a feeling of heaviness in the stomach.
Given the role of gastric motility in the development of symptoms such as a feeling of early satiety, epigastric overcrowding and severity, it becomes evident the need for prokinetic to address these conditions.
To date, one of the most effective drugs in this group is Motilium.

Mechanism of action
Domperidone, Motilium active ingredient, activates peristaltic esophageal contractions and antrum increases the spontaneous activity of the stomach and increases the pressure of the lower esophageal sphincter.
The combined effects on the components of motor function allows to stop a number of symptoms such as feeling of fullness in the epigastric region, and early satiety, nausea, vomiting, discomfort in the epigastric region and swelling that occur in connection with a meal or without it.
Inactivation of the chemoreceptor trigger zone in the bottom of the 4th ventricle, bypassing the blood-brain barrier makes antiemetic effect.

Selection of home kits for the normalization of digestion
In cases where a violation of the digestive processes are not permanent and sporadic, it is necessary to equip a first aid kit home agents that can both aid digestion and quickly relieve the symptoms of indigestion.
Motilium – one of these funds. According to the instructions of these pills can be used without a doctor’s prescription. Their active ingredients normalize gastric motility, helping to eliminate bloating, nausea and overcrowding in it. Ease of use of Motilium tablets allows to use them even in the absence of the usual conditions – on the road, at work and in other situations, as they are easily absorbed and does not require zapivaniya water.
If indigestion symptoms developed into acute (having suddenly and quickly amplified), and if they are observed for a long time – see your doctor for advice and diagnosis.
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